Jardiance Contraindications & Warnings
Jardiance is not the right medication for everyone. Because it works by increasing the kidneys filtration of blood sugar, it is not appropriate for patients with severe or end-stage kidney disease or who are on dialysis. It should also not be given to anyone with a known hypersensitivity to empagliflozin, the active ingredient in Jardiance. In addition, people with diabetic ketoacidosis are not good candidates for Jardiance therapy. Jardiance is not for use in patients with Type 1 diabetes.
Jardiance comes with several warnings, including:
- The potential to cause low blood pressure in the elderly and in patients with renal impairment, low blood pressure, or who are taking diuretics
- The need to monitor patients for signs of
- Ketoacidosis
- Increase in bad cholesterol levels
Overdose: What Happens If I Take Too Much Jardiance
There is limited research on the risk of Jardiance overdose or at what dose Jardiance can become toxic.
A 2020 case report detailed an incident in which a healthy woman overdosed on SGLT-2 inhibitors. Although there was moderate kidney impairment, the only notable side effect was frequent urination. After 36 hours, kidney function returned to normal, and there was no evidence of severe hypoglycemia.
This should not suggest that the risk of Jardiance overdose is lowparticularly in older adults, children, people with kidney disease or heart failure, or those taking certain medications.
Always keep medications out of the reach of children to avoid accidental overdose.
Mixing Empagliflozin With Herbal Remedies And Supplements
There is very little information about taking empagliflozin with herbal remedies and supplements. However, some herbal products such as karela, turmeric and ginseng can potentially cause low blood sugars
It is best to check with your doctor or a pharmacist before taking any herbal remedies or supplements while taking empagliflozin.
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How Does Jardiance Work
Jardiance is a sodium glucose co-transporter 2 inhibitor. It works by blocking the reabsorption of glucose by the kidneys, increasing glucose excretion in urine, and lowering blood sugar levels in people with diabetes. The drugs safety and effectiveness were studied in seven clinical trials of 4,480 patients with Type 2 diabetes. The trials showed that Jardiance improved hemoglobin A1c levels compared to a placebo.
Dr. Gerald Bernstein, director of the diabetes management program at the Friedman Diabetes Institute at Beth Israel Medical Center, and an associate clinical professor of medicine at the Icahn School of Medicine at Mount Sinai in New York, told Healthline, Years ago, a primary goal of diabetes treatment was to keep glucose out of the urine. The ability to do self-blood testing is a much better way to monitor, and people dont have to check their urine as much. In recent years, a new category of drug that causes the body to spill glucose in the urine in a controlled way has emerged. It is normal for a lot of glucose to enter the kidney, but before it gets into the urine, it is reabsorbed back into the bloodstream.
Jardiance can also contribute to a slight reduction in blood pressure, according to Meece.
Is Itching A Side Effect Of Jardiance
Yes, itching is a possible side effect of Jardiance.
In studies, vaginal yeast infections were one of the most common side effects of Jardiance. And itching of the vagina and surrounding area is a common symptom of vaginal yeast infections. Other symptoms include redness or discoloration, pain, swelling, and thick white discharge.
If you have any symptoms of a vaginal yeast infection, call your doctor. Theyll likely recommend an over-the-counter treatment or prescription drug.
Rash and itching werent reported in clinical studies of Jardiance, but they have been reported in people using Jardiance since its been on the market. However, its not known how often these side effects may have occurred or whether Jardiance was the cause.
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Dr Roach: Some Medicines Can Make Blood Sugar Control Harder
Dear Dr. Roach: I have been prediabetic for around 13 years and had been able to keep it that way though diet and exercise no medications for it. But the real issue now is that I have developed congestive heart failure, which probably sounds worse than it really is. However, the medications I have been given for it from my cardiologist and finasteride for prostate issues have totally ruined my glucose numbers. I used to see around 100 in the mornings. I almost never got to the 120s. Now after a couple months on those drugs I am seeing closer to 150 in the morning. After meals the numbers are running nearly 100 points higher than without them. My doctor tried to get me a drug, but that was so expensive as a copay that I had to tell the drugstore I couldnt afford that, which I cant. When I research what to do when your glucose is affected by medication, I get all kinds of sites, but none really seem to have an alternative to the regimen I am now having to take. So, to fix one issue, I fear the diabetes I have worked so hard to contain is going to become a serious problem. What do I do?
L.H.
Heart failure, which is an inability for the heart to supply adequate blood flow for the bodys needs, is a common condition that ranges from very mild to very severe. Heart failure itself is a risk factor for developing diabetes, so it makes sense that new onset heart failure could raise blood sugar in people with prediabetes.
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Side Effects Include Yeast Infections Utis
According to the FDA, Jardiance has been studied as a stand-alone therapy and in combination with other Type 2 diabetes drugs, including metformin, sulfonylureas, pioglitazone, and insulin. The FDA states in a press release that Jardiance should not be used to treat people with Type 1 diabetes for those who have diabetic ketoacidosis or for those with severe renal impairment, end stage renal disease, or for patients on dialysis.
The FDA is requiring four post-marketing studies for Jardiance:
- an ongoing cardiovascular outcomes trial
- a study of how the drug works in the bodies of children and teens
- a pediatric safety and efficacy study
- and a nonclinical juvenile toxicity study with a focus on renal development, bone development, and growth
According to the FDA, Jardiance can cause dehydration, leading to a drop in blood pressure that can result in dizziness or fainting, and a decline in renal function. The elderly, patients with impaired kidney function, and patients taking diuretics to treat other conditions appeared to be more susceptible to this side effect.
The most common side effects of Jardiance are urinary tract infections and female genital infections, especially in those who are prone to these infections.
How Can I Stay Healthy While Taking Jardiance
Medications alone cannot treat type 2 diabetes. Although Jardiance is highly effective, it is meant to be used alongside diet and exercise as part of a holistic treatment plan.
Diets rich in whole grains, fruits, vegetables, legumes, and nuts can improve glycemic control in people with type 2 diabetes. You should reduce intake of refined grains, red/processed meats, and sugar-sweetened foods or drinks. Moderate alcohol consumption is also advised.
According to the American Diabetes Society, people with type 2 diabetes should undertake no less than 150 minutes of moderate to vigorous aerobic exercise per week. In addition to aerobic activities, you should aim to devote two to three days per week to moderate to vigorous resistance training.
Adherence to your treatment plan is key to maintaining optimal glycemic control. Missing doses or failing to follow your diet and exercise plan can take back the gains afforded by drugs like Jardiance. Consistency is key.
If you have trouble following your treatment plan, speak with your healthcare provider. By working together, youll be better able to find the solution best suited for you as an individual.
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Insulin And Insulin Stimulating Medications
Insulin and drugs that increase the bodys production of insulin increase the risk of low blood sugar when theyre taken with Jardiance. Therapy will require regular blood sugar testing, and insulin doses may need to come down.
Some insulin secretagogues are commonly prescribed as a primary therapy along with Jardiance. These include glipizide, glyburide, and glimepiride. Other medications such as nateglinide and repaglinide also cause the body to secrete more insulin. Blood sugar will need to be regularly checked when combining Jardiance with any of these medications.
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What Are The Possible Side Effects Of Jardiance
Jardiance is generally well-tolerated, meaning that not many people experience bothersome side effects.
But, all medications still have potential side effects. Jardiance is no exception. Possible side effects of Jardiance include:
-
Having to urinate more frequently
-
Urinary tract infections
-
Genital infections
-
Upper respiratory infections
But, unlike Invokana, another SGLT2 inhibitor medication that may have heart benefits, Jardiance hasnt been found to raise the risk of bone fractures or amputations.
How Can You Lower Blood Sugar When It Spikes Quickly
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How You Can Help Pinpoint The Problem
If you find that your blood sugar is consistently high when you wake up, you can help diagnose the issue by checking your blood sugar levels during the night.
Dr. Hasan suggests that you set your alarm for 2 or 3 a.m. for a few nights in a row to see what the levels are like during that time. If theyre high then, thats probably a sign of dawn phenomenon, she says.
Financial And Insurance Assistance
If you need financial support to pay for Jardiance, or if you need help understanding your insurance coverage, help is available.
Boehringer Ingelheim and Lilly, the manufacturers of Jardiance, offer a program called Jardiance Savings. For more information and to find out if youre eligible for support, visit the program website.
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Can Jardiance Raise Blood Sugar
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