Focus On Healthier Strategies To Ward Off Diabetes & Heart Disease
Patients should think more about preventing diabetes and cardiovascular disease, says Dr. Zigmont, as obesity is a risk factor for both conditions.
Reinforcing the points made by Dr. Baum, she urges individuals who are concerned about diabetes to put aside any worry about statins, and instead to double down on making lifestyle changes that can go a long way in reducing your risk of developing diabetes. After all, we know that individuals who avoid weight gain, and those who manage to lose weight have the best chance of reversing the fallout of diabetes and can avoid the complications that come with this otherwise chronic, lifelong disease.
Conversely, statins are needed specifically to reduce the risk of heart attack and stroke, and they are incredibly effective at doing so, she says. It is important to take cholesterol-lowering mediation when you have a higher risk of cardiovascular disease, especially if you are a woman in post-menopause.
For those of you who are concerned about side effects, there is anecdotal evidence that changing the brand of statin may relieve some adverse symptoms rather than stopping statin therapy. Also, dose changes can help to manage any negative reactions such as the rare occurance of muscle pain, while still allowing for the huge benefits, lessening the chance that youll have a cardiac event.
Research Design And Methods
In this crossover trial, 50 type 2 diabetic patients were studied to evaluate the effect of pravastatin on plasma coagulation and inflammation markers. A crossover design was chosen to allow treatment comparisons in one subject rather than between subjects and because the sample size needed for detection of treatment effects is smaller. Patients were recruited from the outpatient clinic of the Slotervaart Hospital . Men and women ages 1880 years who were diagnosed with type 2 diabetes for at least 1 year and presented with serum cholesterol levels of 5.010.0 mmol/l were eligible for the study. Patients with acute medical conditions surgery during the previous 3 months deep venous thrombosis or pulmonary embolism during the previous 3 months significant renal, hepatic, metabolic, or thyroid disease alcohol abuse or known familial hypercholesterolemia were excluded. Included patients were not concurrently receiving other lipid-lowering, antithrombotic, or hormonal treatment, but were allowed to use an acetylsalicylic acid. Patients maintained their regular diet during the study period.
Is Over Age 65
“I do what I can to stay active, but my cholesterol levels are still high. My doctor told me a healthy diet and exercise aren’t always enough, and he started me on treatment with ZYPITAMAG.”
Are you over the age of 65? If you are like most Americans over the age of 65 who have high cholesterol, you may be taking other medications along with your statin therapy.
Some statins may have potential drug interactions with certain medications. The unique design of pitavastatin allows this statin to circumvent the common pathways by which drugs are metabolized, thereby reducing the likelihood for certain drug interactions.1
Pitavastatin has been shown to effectively lower LDL cholesterol in persons over the age of 65 with high cholesterol.1 In this study, pitavastatin provides superior LDL cholesterol lowering to Pravachol® . Both pitavastatin and pravastatin have shown comparable tolerability in this patient population.1
If you have high cholesterol and are over the age of 65, ask your doctor about ZYPITAMAG!
Pravachol® is a registered trademark of Bristol-Myers Squibb Company
1 ZYPITAMAG® . Ahmedabad, India: Cadila Healthcare Ltd August 2018
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Niacin To Bring Down Bad Cholesterol
Niacin is a B vitamin available as an over-the-counter supplement. It can have cholesterol-lowering effects, but like statins, it can also raise blood glucose in people with diabetes. A study published in February 2016 in the journal Heart also concluded that niacin increases the risk of developing diabetes in the first place.
Blood Sampling And Laboratory Methods
Blood samples were obtained by standard venepuncture between 9:00 and 11:00 a.m., after a 12-h fast. Total, HDL, and LDL cholesterol triglycerides and fibrinogen were determined using standard laboratory procedures within 1 h after sampling. HDL cholesterol was determined using a direct assay. Safety parameters included creatinine, alanine aminotransferase , aspartate aminotransferase , and creatine phosphokinase were measured with standard techniques. Glycemic control was monitored by evaluating fasting glucose, measured with standard techniques, and HbA1c, determined by high-performance liquid chromatography, as described elsewhere . Levels of high-sensitivity C-reactive protein were determined with a near infrared particle immunoassay rate methodology . Analytical sensitivity, defined as the lowest measurable concentration that can by distinguished from zero with 95% confidence, was 0.2 mg/ml. Measurements of the prothrombin fragment F1 + 2 , the von Willebrand factor antigen , and soluble tissue factor were performed by enzyme-linked immunosorbent assay . d-Dimers were measured with an automated quantitative latex particle immunoassay . Interleukin -12-p70, IL-1, IL-6, IL-10, and IL-8 were measured by cytometric bead array analysis . Tumor necrosis factor- and IL-6 were measured with a high-sensitivity ELISA .
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Decongestants Used To Offer Relief From The Common Cold Or Flu
Decongestant medicines, including Sudafed and phenylephrine, can increase your blood sugar levels. Both are available over the counter, although medication with pseudoephedrine has to be requested from a pharmacist. Many common decongestants use one of these ingredients, so check labels carefully. Short-term use of these is probably okay, but check with your doctor first.
If Statins Raise Blood Sugar Will It Go Back To Normal Once You Stop Statins
- 4 Apr 2012 by auntistatin
- diabetes, type 2
after taking statins for years i was told i had type 2 diabetes… if it is due to statins raising my blood sugar … will it go back to normal once i stop the statinsi stopped taking them a year ago… my blood sugar levels are usually between 5.7 and 6.7 not on any medication
Added 5 Apr 2012:
i take thyroxine for underactive thyroid,atenalol,weigh just under 12 stone…the last blood glucose reading from gp was 5.4 and 5.7 have this done every 3 months
Added 5 Apr 2012:
Your A1-C’s are not that bad, but what does your fasting glucose run?Do you have a genetic predisposition to diabetes etc… Need more answrs to answer your question… Mary
You wil note in the link I gave you that statins are given to people at risk of getting diabetes from high cholesterol, high blood pressure, & heart disease. It did also state if you have a low thyroid you should not be on statins… Mary
thank you for your help i greatly appreciate you taking the time to answer…
thank you mary for taking the time to answer my question… i will look up the liknk you gave me… hope you keep well…
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Statins & Diabetes: Everything You Need To Know
Statins are prescribed to over 200 million people across the globe in an effort to prevent and lower your risk of cardiovascular events like heart attack, stroke, and heart disease.
For people with diabetes, who inevitably face a higher risk of these heart-related conditions, statins could be beneficial but recent research suggests they may actually worsen insulin resistance and increase the likelihood of prediabetes becoming type 2 diabetes.
In this article, well look at the proposed benefits of statins, the side-effects, and the research comparing the benefits vs. the risks, especially regarding insulin resistance.
Taking Statins With Diabetes
Statins work to lower cholesterol levels by blocking a substance your body needs to make cholesterol, therefore decreasing cholesterol made in your liver. They also help lower triglycerides and raise HDL good cholesterol.
Besides improving cholesterol, statins are also associated with a lower risk of heart disease and stroke, which are common comorbidities in diabetes.
People with diabetes are twice as likely to have heart disease or a stroke compared to someone who doesnt have diabetesand at a younger age. The risk for developing heart disease increases the longer you have diabetes.
This is because, over time, high blood glucose levels cause damage to your blood vessels. This damage can obstruct the blood flow to your heart and brain, raising the risk of a stroke or heart attack.
Because of this increased risk, the American Diabetes Association and the American Heart Association recommend statin therapy in addition to lifestyle changes for the prevention of cardiovascular disease in people with diabetes, regardless of cholesterol numbers.
Depending on age, disease status, and other risk factors, the ADA suggests differing intensity levels of statin therapy.
There are other risk factors for heart disease that can also be treated or modified. By doing so, your overall chances of developing heart disease may decrease. These risk factors include:
- High cholesterol
For Example The Analysis Did Not Account For Baseline Glycemic Level
Blood sugar levels chart displays possible levels of blood glucose. As such, it is essential for a person with diabetes to monitor their blood those looking to reduce blood sugar levels should reach for water and avoid all sugary drinks, such as fruit juice or soda, which may raise. Some popular brands associated with high blood sugar levels in study, but odds of problems are low. Find foods that lower blood sugar, and identify foods and activities that raise high blood sugar risks. High blood sugar levels often do not cause symptoms until they run well over 200 mg/dl.
Blood sugar levels chart displays possible levels of blood glucose. You want some insulin to maintain blood glucose levels, but too much of it is badâit’s. You eat, you digest carbs with the help of insulin, a hormone released by the pancreas, and dr. It’s possible that your blood sugar level may slightly increase when you take a statin, which can lead to type 2 diabetes. Keep in mind that foods high in sugar are often high in fat and.
There are many different ways that blood sugar can be affected and if you are a chocoholic and/or have a huge sweet tooth and have diabetes, you do not have to.
Blood sugar is raised by glucose, which is the sugar we get from eating many different types of foods that contain carbohydrates.
Depleting Coq10 Linked To Parkinsons Diabetes Heart Issues
Other identified consequences of taking statins include your bodys ubiquinol levels, which is better known as CoQ10. This coenzyme is a critical part of any human or animals wellbeing, and statins have proven to drop CoQ10 levels in the body by as much as 50 percent, explained Reeves.
Present in every cell of your body, CoQ10 is necessary for the maintenance and production of energy. Its found in concentrated amounts in the tissue of your heart, brain, kidneys, and muscles. Its also a powerful antioxidant and fights-off free radicals that would otherwise damage your cells and DNA.
Significant disabilities might occur quickly in some, or it can take years in others when CoQ10 levels drop this severely, said Reeves.
Low levels of CoQ10 have been linked to diabetes, Parkinson, and other heart problems. In patients who began taking statins prior to developing any of those conditions, experts skeptical of statins postulate that the drug may have contributed to its onset.
A 2015 study from Japan suggests that not only do statins have little or no impact on preventing atherosclerosis, but this drug may also actually cause the buildup and hardening of fats, cholesterol, and plaque in your arteries increasing your risk of a heart attack or stroke.
The epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs, explained the study.
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Research: The Benefits Of Taking Statins
There have been many studies seeking to identify the benefits and risks of taking statins. Like many medications, research can be found both supporting and dissuading the use of this medication.
Both the American Diabetes Association and the American Heart association acknowledge the risks associated with taking statins but argue that the benefits outweigh the risks.
They also emphasize the theory that patients who developed type 2 diabetes after starting statin therapy were already facing a high-risk of the disease, and likely would have developed it anyway.
One of the most significant studies demonstrating the benefits is the Jupiter Trial, which involved 15,000 patients.
The trial showed that compared to patients taking the placebo, patients taking a statin had a 54 percent lower chance of heart attack, 48% lower chance of stroke, 46 percent lower chance of needing angioplasty or coronary artery bypass surgery, and a 20% lower chance of dying from any cause, explains the Cleveland Clinic of the trial.
Another study, Prove IT-TIMI 22, looked at the benefits of statins in patients who had already experienced an acute cardiovascular event, and whether lowering their LDL levels well below 70 mg/dL were more beneficial than lowering to just below 100 mg/dL.
The results showed patients taking a statin in this group had a significantly lower risk of death, heart attack, or stroke.
Statins And Diabetes: No Worries Mate
James P. Smith, M.D., M.S., is deputy director of the Division of Metabolism and Endocrinology at the FDA. An agency article titled Controlling Cholesterol with Statins offers the following:
Ive heard that there are some risks to taking statins. Should I be worried?
Statins are typically very well tolerated. Two risks that patients may be aware of are muscle-related complaints and an increased risk of developing type 2 diabetes. Muscle complaints are quite common even among people not taking statins, so it is important to have your healthcare provider evaluate any symptoms before stopping your medication, Smith explains. It is rare for statins to cause serious muscle problems.
Similarly, the risk of developing diabetes as a result of a statin is small. The benefits of statins in reducing heart attacks and strokes should generally outweigh this small increased risk, Smith says.
Were not as convinced that elevations in blood sugar brought on by statins are not very worrisome. Whenever someone develops diabetes, we are concerned. Thats because of the serious consequences of this metabolic disorder.
You may be surprised to learn that not all physicians agree about how to treat diabetes. Here are two recent articles demonstrating serious differences of opinion:
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Certain Antibiotics To Address Infections Such As Utis And Pneumonia
A class of antibiotics called fluoroquinolones, used to treat illnesses like pneumonia and urinary tract infections , has been shown to cause both very low and high blood sugar, a study published in October 2013 in the journal Clinical Infectious Diseases found. In addition, pentamidine, an antimicrobial drug used to treat a certain kind of pneumonia, can also cause a rise in blood sugar.
Atorvastatin Lowers Cholesterol But Raises Blood Sugar
As many as 40 million people may be taking statin-type cholesterol-lowering drugs daily in the U.S. Although medications like atorvastatin, lovastatin, simvastatin, pravastatin, and rosuvastatin can bring cholesterol levels down dramatically they can also raise blood glucose levels or make diabetes harder to control as this reader relates:
Q. I used to have good blood sugar readings when I was on glyburide. Since I was put on atorvastatin to lower cholesterol I have had trouble with high blood sugar.
I read in your Guide to Managing Diabetes that statins can affect blood glucose but the clinical pharmacist at the VA said you are wrong. She insisted that atorvastatin does not affect HbA1c or blood sugar.
They now have me on both glipizide and Onglyza and the clinical pharmacist admitted that my HbA1c will not come down. She still insists I have to keep taking these medicines even if they are not working to control my diabetes.
A. We are puzzled that your pharmacist was not aware of the official prescribing information for atorvastatin : Increases in HbA1c and fasting serum glucose levels have been reported with HMG-CoA reductase inhibitors , including LIPITOR.
HbA1c is a measure of how high blood sugar levels have been over the past three months. Clinical trials and other studies have shown that statins can indeed raise blood sugar levels, making it harder to control diabetes.
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A Reader Complains About Statins And Diabetes:
Q. Statins raise blood sugar. I took them twice and both times my blood sugar got out of control.
When that happened, the doctor prescribed meds for diabetes. I felt fine without the drugs, but the medicines made me feel sick.
The answer was to take more meds, both the statin and the diabetes drugs. Am I really a diabetic if my blood sugar is high only when I am taking a statin?
A. You raise a fascinating question. Most experts in cardiology and metabolic disorders insist that all patients with diabetes should be on statins. We often read articles that begrudgingly admit that statins may slightly raise blood sugar levels.
The specialists suggest, however, that this is not that big a deal. Any elevation in blood sugar is theoretically outweighed by the overwhelming benefits of statins. A connection between statins and diabetes should, they say, not be a cause for alarm.
For Diabetics The Correct Statin Matters
Statins can increase serum glucose and increase the risk of developing diabetes in certain patients, but that doesnt mean your diabetic patients shouldnt take them. In fact, the American College of Cardiology / American Heart Association cholesterol treatment guidelines say that the occurrence of a major ASCVD event represents a much greater harm to health status than does an increase in blood glucose. The Food and Drug Administration concurs, noting in its safety label change on statins that the cardiovascular benefits of the widely used drugs typically outweighs the disadvantages of modestly higher blood sugar levels or incident diabetes.
Still, when youre treating a patient with diabetes, you would rather have all the medications working to improve blood glucose levels. Careful selection of the right statin can keep from reversing some hard-earned progress in reducing HbA1c levels, according to a study published online ahead of print in the December issue of Current Cardiovascular Risk Reports.
Because patients with diabetes also have an increased risk of ASCVD events, statins may provide a greater benefit to them than to patients without diabetes and should be recommended in keeping with current guidelines. Selection of an agent with less effect on serum glucose provides an opportunity to potentially prevent a stroke or myocardial infarction without worsening a patients HbA1c and increasing the risks associated with hyperglycemia.
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